En gruppe lidelser og tilstander i hjernen som kan forårsake funksjonsforstyrrelser som karakteriseres av ulike previous av anfall, enten med eller uten innvirkning på bevisstheten, og med eller uten krampeanfall.
Modafinil excels at what it absolutely was initially built to do: it encourages wakefulness, boosts alertness, and enhances psychological operate in a very snooze-deprived state.
Membranbundet enzym som finnes i mange av kroppens vev og som katalyserer hydrolyse av peptider og overføring av glutamylgrupper til aminosyrer og peptider.
modafinil will enhance the degree or impact of diazepam buccal by impacting hepatic enzyme CYP2C19 metabolism. Use Warning/Observe. Potent or moderate CYP2C19 inhibitors may possibly reduce level of diazepam elimination, thus rising adverse reactions to diazepam.
Obstructive rest apnea, a problem that comes about when your respiratory stops and commences When you slumber since your airway gets blocked
eslicarbazepine acetate will improve the stage or result of modafinil by impacting hepatic enzyme CYP2C19 metabolism. Use Warning/Observe.
In foreseeable future studies, system of modafinil will keep on to be examined for the reason that modafinil may well create achievable abuse and habit and its waking mechanism get more info has not been fully elucidated [36,forty five].
fedratinib will raise the stage or result of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of. Regulate dose of medicine which have been CYP3A4 substrates as required.
The duration of the impact was longest for dextroamphetamine and shortest for caffeine. At earlier mentioned doses, caffeine turned out to get quite possibly the most "subjectively documented side effects", accompanied by dextroamphetamine. Dextroamphetamine was the only stimulant that had adverse results on subsequent recovery rest. Modafinil didn't present major, subjectively-documented side-results nor subsequent Restoration sleep when compared to placebo. The success of those a few stimulants is organized in Table 1.
Modafinil has consistently been shown to efficiently protect against excessive daytime sleepiness devoid of disrupting ordinary nighttime snooze, which makes it a particularly beneficial remedy for people with narcolepsy[seven] or similar slumber Conditions for example obstructive rest apnea.[8]
Belzutifan is really a CYP2C19 substrate. Coadministration with CYP2C19 inhibitors could boost incidence or severity of adverse effects. Keep track of for anemia and hypoxia and cut down belzutifan dose as encouraged.
tazemetostat will reduce the extent or result of modafinil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.
Use with warning in serious hepatic impairment, aged, and individuals that has a historical past of despair or psychosis (modafinil may exacerbate psychiatric symptoms) or mania
DailyMed will provide notification of updates and additions to Drug Label facts currently demonstrated on this site by means of its RSS feed.